Purpose of the study: Hypofunctioning breasts are typically considered a dysfunction of higher brain centers that regulate hormonal feedback, and olfactory information has been proposed as a triggering factor for lactation in the maternal body. However, there are no substantive studies regarding whether olfaction disorders and/or loss of olfactory sense may result in breast gland atrophy by causing diminished olfactory stimulation. To fill this gap in the literature, we studied the histologic features of breast glands as a sample model in animals that had undergone an olfactory bulb lesion (OBL).

Materials and methods: This study was conducted on 22 rats. Six, eight, and six of them were used as control, SHAM, and OBL groups, respectively. After 10 weeks, the animals were decapitated. Olfactory bulbs and breast glands were stained with Hematoxylin-eosin and tunnel dye. Specimens were analyzed stereologically to evaluate the loss in volume of the olfactory bulbs, total breast follicle volüme (TBFV) and Meissner’s corpuscles per cubic centimeter, and these two senior metrics were compared with each other statistically. Results:Olfactory bulb volume loss and breast gland atrophywere both detected in study group. Mean TBFV and OB volumesweremeasured as: (296 °æ 89) °ø106 μm3/cm3 and 4.43 °æ 0.98mm3 in control (Group I); (264 °æ 63) °ø 106 μm3/cm3 and 3.86 °æ 0.81 mm3 in SHAM (Group II) and (194 °æ 52) °ø 106 μm3/cm3 and 1.52°æ0.36mm3 in OBLgroup (Group III). It was noted that the TBFVwas significantly diminished, with apoptotic degradation in the olfactory bulbs and breast glands of OBL-applied animals (p < 0.001).

Conclusion: It seems that diminished milk secretion is attributable to the degradation of breast glands that results from olfaction loss in OBL animals.