Fetal effects of drugs used during pregnancy can mainly occur as intrauterine death, teratogenicity and organ malformations, growth retardation, toxic effect, toxicity in the neonatal period and withdrawal symptoms, and in the long-term neurobehavioral problems. While lithium, one of the mood stabilizers, unlike the old information became a more innocent drug with recent data; valproic acid, which has been more widely used in recent years, became a risky drug especially in perinatal period because of neural tube defects. Lamotrigine seems to have lower risk in mood disorder cases with depressive episodes. References about short and long term effects of typical antipsychotics on fetus is higher than that of atypical ones, suggesting not more risk than the risk in general population in terms of congenital anomalies. Still, their extrapyramidal system (EPS) side effect potential on fetus during postpartum period, limits their usage. Although atypical antipsychotics are more reliable in this respect, they require a careful patient selection and careful and regular monitoring in terms of complications because of having metabolic side effects resulting in pregnancy complications and causes long term tendency of fetus to diseases of the cardiovascular system. Especially in the first three months of pregnancy, using single medication with lowest effective dose will decrease the fetal exposure to drug and provide a safer course of pregnancy. Having regard to the factors such as the individual course of the disease and living conditions and deciding with family will be the best approach while evaluating the effects and the risks of the drugs on fetus.