Women have more complex endocrine system versus men in all through their lives. The cyclical flux of hormones is admitted as the triggering factor both in negative and positive way in the ethiology of many psychiatric diseases. Having an early or late onset menarche seem to be responsible for many psychiatric projections. ''Repruductive Depression'' so called to enclose premenstrual, postnatal and climacteric ones outlines the long term effect of homones on women's lives. Even an irregular hormone system can be decisive to clinical response to psychiatric medication whereas some medications used to treat bipolar disorder or schizophrenia, like anti-epileptic drugs or antipsychotics can cause menstrual abnormalities and polycystic ovary syndrome characterized by chronic anovulation and hyperandrogenism. Enlightening endocrine system seems to be vital in order to understand the women's mental health, not only to understand the ethiology but also opening new gates to improve treatment response and a better quality of life.