Objectives: The effects of the three antipsychotropic drugs, haloperidol, risperidone and olanzapine on lipid peroxidation and some oxidant and antioxidant enzyme activities in liver tissue in rats were studied.
Methods: Haloperidol (0.4 and 0.8 mg/kg), risperidone (0.5 and 1 mg/kg), and olanzapine (2 and 4 mg/kg) were administrered intraperitoneally to rats once a day for 6 weeks. There were 6 rats for each subgroup and also in the control group. Malondialdehyde(MDA) level, and the activities of xanthine oxidase(XO),superoxide dismutase, catalase(CAT) and glutathione peroxidase(GP) in liver tissue were measured by spectrophotometric methods. The differences among the means of the first and second doses were evaluated by One-way ANOVA with post-hoc LSD test, seperately. The difference between first and second doses was tested by Mann-Whitney U test.
Results: Haloperidol and risperidone did not affect the liver MDA level in both dose levels. However, olanzapine decreased the liver MDA level in high dose. Haloperidol increased the GPx at low dose. When it is administered in high döşe a decrease was found in XO. When the two dose levels were compared, MDA level, and activities of XO and GPx were lower in high dose group. Risperidone decreased XO activity in low dose while it increased CAT activity in high dose. When the two dose levels were compared, MDA level was decreased, while XO activity was increased in high dose group. Olanzapine decreased XO activity only at high dose. When first doses of the three drugs and control group were compared, XO level was lower in risperidone group compared with haloperidol receiving group. GPx activity of haloperidol was higher than risperidone and olanzapine at lower dose. There were no difference among the effects of the three drugs at high dose.
Conclusion: Our results demonstrated that these three antipsychotic drugs does not increase lipid peroxidation in liver tissue in the doses administered in this study, however, superoxide producing XO activity was decreased by haloperidol and olanzapine at high dose, and risperidone at low dose, while the antioxidant GPx activity was increased by haloperidol at low dose, and CAT activity by risperidone at low dose. These alterations due to these drugs did not increase the oxidative stress in liver tissue in rats in this study.
This study was carried out in accordance with the Declaration of Helsinki.