Brain pathologies such as cerebrovascular disease, head trauma, brain tumors, brain infections, neurodegenerative diseases that damage the frontal lobes can also result in profound changes in personality and social adjustment. Dysfunctions of the frontal lobes result a relatively specific clinical syndromes. Case reports and imaging studies have implicated that the patients with lateral prefrontal damage may show apathy, indifference, speech poverty, and poor executive abilities. On the other hand, damage to the ventromedial prefrontal cortex may lead to poor impulse control, puerility, euphoria, increased energy, aggression, violence and sociopathy. The frontal lobe is the largest lobe in the brain, yet it is often not specifically evaluated in routine neurologic examinations. When a patients history suggests frontal lobe dysfunction, a detailed neurobehavioral evaluation is necessary to probe frontal lobe functions.